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Estimates of systolic and diastolic myocardial blood flow by dynamic contrast-enhanced MRI

✍ Scribed by Aleksandra Radjenovic; John D. Biglands; Abdulghani Larghat; John P. Ridgway; Stephen G. Ball; John P. Greenwood; Michael Jerosch-Herold; Sven Plein

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
428 KB
Volume
64
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Myocardial blood flow varies during the cardiac cycle in response to pulsatile changes in epicardial circulation and cyclical variation in myocardial tension. First‐pass assessment of myocardial perfusion by dynamic contrast‐enhanced MRI is one of the most challenging applications of MRI because of the spatial and temporal constraints imposed by the cardiac physiology and the nature of dynamic contrast‐enhanced MRI signal collection. Here, we describe a dynamic contrast‐enhanced MRI method for simultaneous assessment of systolic and diastolic myocardial blood flow. The feasibility of this method was demonstrated in a study of 17 healthy volunteers at rest and under adenosine‐induced vasodilatory stress. We found that myocardial blood flow was independent of the cardiac phase at rest. However, under adenosine‐induced hyperemia, myocardial blood flow and myocardial perfusion reserve were significantly higher in diastole than in systole. Furthermore, the transmural distribution of myocardial blood flow and myocardial perfusion reserve was cardiac phase dependent, with a reversal of the typical subendocardial to subepicardial myocardial blood flow gradient in systole, but not diastole, under stress. The observed difference between systolic and diastolic myocardial blood flow must be taken into account when assessing myocardial blood flow using dynamic contrast‐enhanced MRI. Furthermore, targeted assessment of systolic or diastolic perfusion using dynamic contrast‐enhanced MRI may provide novel insights into the pathophysiology of ischemic and microvascular heart disease. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.

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