Characterization of t1 relaxation and blood-myocardial contrast enhancement of NC100150 injection in cardiac MRI

In vivo Characterization of Gd(BME-DTTA)

In vivo Characterization of Gd(BME-DTTA), a myocardial MRI contrast agent: tissue distribution of its MRI intensity enhancement, and its effect on heart function

✍ Wen-Jang Chu; Tamas Simor; Gabriel A. Elgavish 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 466 KB 👁 2 views

We have determined an LD 50 of 0.56 ± 0.05 mmol/kg for liposomal Gd(BME-DTTA) in mice and also shown that liposomal Gd(BME-DTTA) has no deleterious effects on heart rate, blood pressure, left ventricular force and AV conductance in ferret hearts in vivo at the magnetic resonance imaging (MRI)-effect