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Esperamicins, a novel class of potent antitumor antibiotics. 2. Structure of esperamicin X

✍ Scribed by Golik, Jerzy; Clardy, Jon; Dubay, George; Groenewold, Gary; Kawaguchi, Hiroshi; Konishi, Masataka; Krishnan, Bala; Ohkuma, Hiroaki; Saitoh, Kyoichiro; Doyle, Terrence W.


Book ID
127277774
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
289 KB
Volume
109
Category
Article
ISSN
0002-7863

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Synthesis of the core enediyne structure
✍ Kiyoshi Tomioka; Hitoshi Fujita; Kenji Koga πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 285 KB

The core structure of esperamicin-calichemicin series, bicyclo[7.3.l]enediyne 2, was synthesized in 9% overall yield in eight steps from cycbhexane-I ,2-dione and was shown to be stable at room temperature. The heart of esperamicin-calichemicin class of novel antitumor antibiotics (e.g., 1) is a bic