✦ LIBER ✦
Synthetic studies on the esperamicin/calicheamicin antitumor antibiotics. Selenium dioxide oxidation of a bridgehead trialkylsilyl enol ether
✍ Scribed by Philip Magnus; Frank Bennett
- Book ID
- 104232911
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 185 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Oxidation of the bridgehead r-butyldimethylsilyl enol ether 4 with selenium dioxide at 25°C produces the stable hemihydrate 6, which on further oxidation gave the allylic alcohol 8.