Synthesis of the core enediyne structure
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Kiyoshi Tomioka; Hitoshi Fujita; Kenji Koga
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Article
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1989
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Elsevier Science
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French
β 285 KB
The core structure of esperamicin-calichemicin series, bicyclo[7.3.l]enediyne 2, was synthesized in 9% overall yield in eight steps from cycbhexane-I ,2-dione and was shown to be stable at room temperature. The heart of esperamicin-calichemicin class of novel antitumor antibiotics (e.g., 1) is a bic