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Biosynthesis of esperamicin A1, an enediyne antitumor antibiotic

✍ Scribed by Lam, Kin Sing; Veitch, Judith A.; Golik, Jerzy; Krishnan, Bala; Klohr, Steven E.; Volk, Kevin J.; Forenza, Salvatore; Doyle, Terrence W.


Book ID
126236682
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
697 KB
Volume
115
Category
Article
ISSN
0002-7863

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Synthesis of the core enediyne structure
✍ Kiyoshi Tomioka; Hitoshi Fujita; Kenji Koga πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 285 KB

The core structure of esperamicin-calichemicin series, bicyclo[7.3.l]enediyne 2, was synthesized in 9% overall yield in eight steps from cycbhexane-I ,2-dione and was shown to be stable at room temperature. The heart of esperamicin-calichemicin class of novel antitumor antibiotics (e.g., 1) is a bic