ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest
β Scribed by Todd, Daniel E; Densham, Ruth M; Molton, Sarah A; Balmanno, Kathryn; Newson, Catherine; Weston, Claire R; Garner, Andrew P; Scott, Linda; Cook, Simon J
- Book ID
- 110068543
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 525 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Transforming growth factor-β€1 (TGF-β€) inhibits cell-cycle progression of many types of cells by arresting them in G 1 /S phase through inhibition of the active cyclin-Cdk complexes that lead to inhibition of Rb phosphorylation. In gastriccancer cells, SNU16, TGF-β€ treatment induced enhanced exp
Pyrrolidine dithiocarbamate (PDTC), a metal chelating compound, is known to induce cell death in vascular smooth muscle cells (VSMC). However, the molecular mechanism for PDTC-induced VSMC death is not well understood. Addition of PDTC reduced cell growth and DNA synthesis on VSMC in low density con