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EPSP Synthase: The Design and Synthesis of Bisubstrate Inhibitors Incorporating Novel 3-Phosphate Mimics

โœ Scribed by Sikorski, James A.; Miller, Michael J.; Braccolino, Diane S.; Cleary, Darryl G.; Corey, Susan D.; Font, Jose' L.; Gruys, Kenneth J.; Han, C. Y.; Lin, Ko-Chung; Pansegrau, Paul D.; Ream, Joel E.; Schnur, Dora; Shah, Ajit; Walker, Mark C.


Book ID
120358311
Publisher
Taylor and Francis Group
Year
1993
Tongue
English
Weight
232 KB
Volume
76
Category
Article
ISSN
1042-6507

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๐Ÿ“œ SIMILAR VOLUMES


New EPSP synthase inhibitors: Synthesis
โœ Michael J. Miller; Darryl G. Cleary; Joel E. Ream; Kristin R. Snyder; James A. S ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 719 KB

A new analog of the EPSP synthase enzyme reaction intermediate 1, containing a 3-malonate ether moiety in place of the usual 3-phosphate group, was synthesized from 3,5-dihydroxybenzoic acid. This simple, synthetically accessible aromatic compound (5) is an effective competitive inhibitor versus S3P