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ChemInform Abstract: New Simplified Inhibitors of EPSP Synthase: The Importance of Ring Size for Recognition at the Shikimate 3-Phosphate Site.

โœ Scribed by M. L. PETERSON; S. D. COREY; J. L. FONT; M. C. WALKER; J. A. SIKORSKI


Book ID
101842072
Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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New simplified inhibitors of EPSP syntha
โœ Mark L. Peterson; Susan D. Corey; Jose L. Font; Mark C. Walker; James A. Sikorsk ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 291 KB

The simple 4-[(a-hydroxy)phosphonomethyl]-lH-pyrrole-2-carboxylate 4 is a surprisingly good S3Panalog inhibitor of EPSP synthase (competitive with S3P, Ki(app) = 14.5 + 0.7 laM). The affinity of 4 for free enzyme is nearly comparable to that of S3P (K d = 7 + 1.2 IxM). Compound 4 thus represents the