New simplified inhibitors of EPSP syntha
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Mark L. Peterson; Susan D. Corey; Jose L. Font; Mark C. Walker; James A. Sikorsk
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Article
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1996
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Elsevier Science
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English
โ 291 KB
The simple 4-[(a-hydroxy)phosphonomethyl]-lH-pyrrole-2-carboxylate 4 is a surprisingly good S3Panalog inhibitor of EPSP synthase (competitive with S3P, Ki(app) = 14.5 + 0.7 laM). The affinity of 4 for free enzyme is nearly comparable to that of S3P (K d = 7 + 1.2 IxM). Compound 4 thus represents the