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EPSP synthase inhibitor design II. The importance of the 3-phosphate group for ligand binding at the shikimate-3-phosphate site & the identification of 3-malonate ethers as novel 3-phosphate mimics.

โœ Scribed by Michael J. Miller; Karen S. Anderson; Diane S. Braccolino; Darryl G. Cleary; Kenneth J. Gruys; C.Y. Han; Ko-Chung Lin; Paul D. Pansegrau; Joel E. Ream; R. Douglas Sammons; James A. Sikorski


Book ID
108476925
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
442 KB
Volume
3
Category
Article
ISSN
0960-894X

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๐Ÿ“œ SIMILAR VOLUMES


New simplified inhibitors of EPSP syntha
โœ Mark L. Peterson; Susan D. Corey; Jose L. Font; Mark C. Walker; James A. Sikorsk ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 291 KB

The simple 4-[(a-hydroxy)phosphonomethyl]-lH-pyrrole-2-carboxylate 4 is a surprisingly good S3Panalog inhibitor of EPSP synthase (competitive with S3P, Ki(app) = 14.5 + 0.7 laM). The affinity of 4 for free enzyme is nearly comparable to that of S3P (K d = 7 + 1.2 IxM). Compound 4 thus represents the