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Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-d-manno-octulosonate 8-phosphate synthase

โœ Scribed by Aidan N. Harrison; Sebastian Reichau; Emily J. Parker


Book ID
113496474
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
591 KB
Volume
22
Category
Article
ISSN
0960-894X

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3-Deoxy-D-manm-octulosonate-8-phosphate (KDOP) synthase catalyzes the production of KDOP from phosphoenolpyruvate (PEP) and arabinose-5-phosphate (A5P). In gram-negative bacteria KDOP is subsequently dephosphorylated, cytidylylated, and linked to lipid A and is required for lipid A incorporation int