Epigenetic abnormalities in cutaneous squamous cell carcinomas: frequent inactivation of the RB1/p16 and p53 pathways
โ Scribed by K. Murao; Y. Kubo; N. Ohtani; E. Hara; S. Arase
- Book ID
- 108669040
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 233 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0007-0963
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Abnormalities in the p53 gene were studied in a series of cell lines of human squamous-cell carcinoma of the head and neck (SCCHN) and in tumor tissues. Restriction-fragment-length polymorphism (RFLP), quantitative hybridization and immunochemical analysis of mutant p53 proteins were combined to det