## Background: The prognostic significance of the invasive tumor front in squamous cell carcinomas has recently been recognized. the aim of the present study was to investigate possible molecular mechanisms underlying the significance of this area in oral squamous cell carcinomas. ## Methods: We
Abnormalities of the ARF-p53 pathway in oral squamous cell carcinoma
β Scribed by Bradley, Grace; Irish, Jonathan; MacMillan, Christina; Mancer, Kent; Witterick, Ian; Hartwick, Warren; Gullane, Patrick; Kamel-Reid, Suzanne; Benchimol, Sam
- Book ID
- 110064433
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 423 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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To examine the expression of p53 protein and gene alterations in oral epithelial lesions including epithelial dysplasias and primary squamous cell carcinomas, immunohistochemical and temperature gradient gel electrophoresis (TGGE) methods were applied to formalin-fixed and paraffin-embedded tissues.
Previous studies of oral cancer have suggested that alterations of the p53 tumour suppressor gene occur early in the precancerous stage of development. However, these observations have been based on cross-sectional assessment of abnormal p53 protein staining by immunohistochemistry and may not neces