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Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma

✍ Scribed by Okami, K; Reed, A L; Cairns, P; Koch, W M; Westra, W H; Wehage, S; Jen, J; Sidransky, D


Book ID
110062252
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
217 KB
Volume
18
Category
Article
ISSN
0950-9232

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To evaluate the prognostic significance of cyclin D1 protein/gene expressions in human head-and-neck squamous-cell carcinoma (HNSCC), we examined amplification of the cyclin-D1 gene (CCND1) by the differential PCR method and over-expression of cyclin-D1 protein by immunohistochemistry in 45 paraffin