## Background. Abnormalities in chromosome llq13 regions have been frequently found in head and neck squamous carcinoma. Recent studies indicate that the PRAD-1 (also CCNDI), which encodes cyclin D1, is a putative oncogene that is an important component of this region. Methods. DNA was extracted
Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma
β Scribed by Okami, K; Reed, A L; Cairns, P; Koch, W M; Westra, W H; Wehage, S; Jen, J; Sidransky, D
- Book ID
- 110062252
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 217 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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## Background: Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck (scchn). the oncogene ccnd1 is located at 11q13 and encodes cyclin d1, a cell cycle-regulating protein. the authors investigated the clinical relevance and associations between amplifi
To evaluate the prognostic significance of cyclin D1 protein/gene expressions in human head-and-neck squamous-cell carcinoma (HNSCC), we examined amplification of the cyclin-D1 gene (CCND1) by the differential PCR method and over-expression of cyclin-D1 protein by immunohistochemistry in 45 paraffin