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Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1α in non-small cell lung cancer cells

✍ Scribed by Xu, L; Nilsson, M B; Saintigny, P; Cascone, T; Herynk, M H; Du, Z; Nikolinakos, P G; Yang, Y; Prudkin, L; Liu, D


Book ID
109972361
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
780 KB
Volume
29
Category
Article
ISSN
0950-9232

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✍ Daniel E.B. Swinson; J. Louise Jones; Giles Cox; Donna Richardson; Adrian L. Har 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 199 KB

## Abstract Hypoxia‐inducible factor (HIF)‐1α is the regulatory subunit of HIF‐1 that is stabilized under hypoxic conditions. Under different circumstances, HIF‐1α may promote both tumorigenesis and apoptosis. There is conflicting data on the importance of HIF‐1α as a prognostic factor. This study