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Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancers

✍ Scribed by Yuji Hirami; Motoi Aoe; Kazunori Tsukuda; Fumikata Hara; Yu Otani; Ryuichiro Koshimune; Tetsuro Hanabata; Itaru Nagahiro; Yoshifumi Sano; Hiroshi Date; Nobuyoshi Shimizu


Book ID
116333171
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
346 KB
Volume
214
Category
Article
ISSN
0304-3835

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Hypoxia-inducible factor-1α in non small
✍ Daniel E.B. Swinson; J. Louise Jones; Giles Cox; Donna Richardson; Adrian L. Har 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 199 KB

## Abstract Hypoxia‐inducible factor (HIF)‐1α is the regulatory subunit of HIF‐1 that is stabilized under hypoxic conditions. Under different circumstances, HIF‐1α may promote both tumorigenesis and apoptosis. There is conflicting data on the importance of HIF‐1α as a prognostic factor. This study