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Eosinophil activation by lymphokines and T cell clone products in the rat

✍ Scribed by Monica Veith; Jöel Pestel; Sylvie Loiseau; Monique Capron; André Capron

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
791 KB
Volume
15
Category
Article
ISSN
0014-2980

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✦ Synopsis

T cell lines and T cell clones derived from inbred Fischer rats and specific for Schistosoma mansoni antigens were established. Cell-free supernatants from the T cell lines demonstrated a marked capacity to enhance IgE-and IgGa-dependent eosinophil-mediated killing of S. mansoni larvae in vitro. In addition, supernatants from cloned T cells stimulated with concanavalin A or specific antigen, or unstimulated, enhanced IgE-dependent eosinophil-mediated helminthotoxicity. The enhancing activity in both cases was very heat-stable (lOO°C, 10 min). We also found that clone-derived supernatants enhance eosinophil peroxidase release upon stimulation with homologous IgE and anti-IgE as well as inducing a more delayed spontaneous release of peroxidase. In view of the established thymus dependency for the development of immunity to schistosomiasis in the rat, the availability of these s. mansonispecific cloned T cells has enabled the relationship between eosinophils, lymphocytes and anaphylactic antibodies to be examined more closely.

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