Enzymic synthesis of galactopyranosyl-l-serine derivatives using galactosidases
✍ Scribed by Danièle Cantacuzene; Sandra Attal
- Book ID
- 102995923
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 302 KB
- Volume
- 211
- Category
- Article
- ISSN
- 0008-6215
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A/tstraet:. l~e coupling of the D-serinal derivative 7 with the l~.~Al~ynmosyimethylene phosph(nne generated from the phosphouium salt 6 and reduction of the resulting aHume led to the C.glycosylated amino alcohol 9 that in tmn was oxidized to Ihe title mdno acid in 44% overall yield.
An efficient route for the synthesis of Gal ~I-3GalNAc~ l -O-Serine derivative was developed using a novel [31-3 galactosidase obtained from Bacillus circulans. By a transglycosylation reaction with pNP-~-Gal 2 as a donor and GalNAc~.I-O-Z-Ser-OAII 4 as an acceptor, GaI!31-3GalNAca-I-O-Z-Ser-OAII 5