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An efficient synthesis of a Galβ1-3GalNAc-Serine derivative using β-galactosidase

✍ Scribed by Katsuhiko Suzuki; Hiroshi Fujimoto; Yoshiyuki Ito; Takashi Sasaki; Katsumi Ajisaka

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
180 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient route for the synthesis of Gal ~I-3GalNAc~ l -O-Serine derivative was developed using a novel [31-3 galactosidase obtained from Bacillus circulans. By a transglycosylation reaction with pNP-~-Gal 2 as a donor and GalNAc~.I-O-Z-Ser-OAII 4 as an acceptor, GaI!31-3GalNAca-I-O-Z-Ser-OAII 5 was synthesized in 68% yield.

📜 SIMILAR VOLUMES

Chemoenzymatic synthesis of Gal(β1-3)Gal
Chemoenzymatic synthesis of Gal(β1-3)Gal(β1-4)Xyl(β)-l-Ser and Gal(β1-3)Gal(β1-4)Xyl(β)-MU by the use of β-d-galactosidase
✍ Koichi Fukase; Takashi Yasukochi; Yasuo Suda; Masao Yoshida; Shoichi Kusumoto 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 298 KB

The title trisaccharide-serine conjugate 1 constituting the linkage region between glycoaminoglycaa and I~otein in proteoglycan, was synthesized via a Ixisacchm~k p-nitrophenyl (PNP) glycoside prepared by stepwise enzymatic transglycosidation to XyI-PNP with a ~-D-galactosidase. In the second tnmsgl