## Abstract D,L‐3‐[^11^C]‐Alanine was prepared by methylation with ^11^CH~3~I of tert butyl 2‐isocyanoacetate and subsequent hydrolysis. Enzymatic reaction using glutamate pyruvate transaminase and lactate dehydrogenase in a coupled reaction yields L‐3‐[^11^C]‐lactic acid. The radiochemical yield i
✦ LIBER ✦
Enzymatic synthesis of 11C-pyruvic acid and 11C-L-lactic acid
✍ Scribed by Marvin B. Cohen; Leonard Spolter; Chia C. Chang; Joseph S. Cook; Norman S. Macdonald
- Book ID
- 107769024
- Publisher
- Elsevier Science
- Year
- 1980
- Weight
- 363 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0020-708X
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## Abstract The synthesis of 1‐ and 3‐^11^C‐labelled L‐lactic acid from the corresponding racemic 1‐ or 3‐^11^C‐labelled alanine using a multi‐enzymatic reaction route, is presented. DL‐[1‐^11^C]Alanine was synthesised by reacting sodium 1‐hydroxy‐ethyl sulfite with hydrogen [^11^C]cyanide, obtaine
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