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Enzymatic resolution of racemic ibuprofen by surfactant-coated lipases in organic media

✍ Scribed by Masahiro Goto; Sadafumi Noda; Noriho Kamiya; Fumiyuki Nakashio

Publisher
Springer Netherlands
Year
1996
Tongue
English
Weight
286 KB
Volume
18
Category
Article
ISSN
0141-5492

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✦ Synopsis

Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with a nonionic surfactant. The reaction rates of the coated lipases were increased around 100-fold that of the powder lipases.

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