Enzymatic resolution of racemic ibuprofe
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Masahiro Goto; Sadafumi Noda; Noriho Kamiya; Fumiyuki Nakashio
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Article
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1996
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Springer Netherlands
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English
⚖ 286 KB
Surfactant-coated lipases have been utilized as a biocatalyst for the resolution of racemic ibuprofen. S-(+)-ibuprofen was selectively transferred to the ester form by Mucor javanicus or Candida rugosa lipase. The enzymatic activity of lipases in organic media was remarkably enhanced by coating with