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Entacapone: more ‘on’ time for patients with Parkinson’s disease

Book ID
120875658
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
1997
Weight
252 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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## Abstract Entacapone (EN) improves the efficacy of levodopa/dopadecarboxylase inhibitor (LD/DDI) formulations by inhibition of the enzyme catechol‐__O__‐methyltransferase (COMT). COMT inhibition also promotes the synthesis of basic LD metabolites, whereas DDI support the composition of acidic LD