Entacapone improves complex movement performance in patients with Parkinson’s disease
✍ Scribed by Thomas Müller; Christoph Erdmann; Siegfried Muhlack; Dirk Bremen; Horst Przuntek; Dirk Woitalla
- Book ID
- 116673953
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 127 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0967-5868
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## Abstract Entacapone (EN) improves the efficacy of levodopa/dopadecarboxylase inhibitor (LD/DDI) formulations by inhibition of the enzyme catechol‐__O__‐methyltransferase (COMT). COMT inhibition also promotes the synthesis of basic LD metabolites, whereas DDI support the composition of acidic LD
## Abstract Mirror movements (MM) refer to ipsilateral involuntary movements that appear during voluntary activity in contralateral homologous body regions. This study aimed to compare the frequency and distribution of MM in an unselected sample of 274 patients with Parkinson's disease (PD) and 100