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Bimodal administration of entacapone in Parkinson’s disease patients improves motor control

✍ Scribed by L. Bet; S. R. Bareggi; F. Pacei; G. Bondiolotti; G. Meola; A. H. V Schapira

Book ID
111065389
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
170 KB
Volume
15
Category
Article
ISSN
1351-5101

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Entacapone improves absorption of a coadministered salt in patients with Parkinson's disease
✍ Thomas Müller; Dirk Woitalla; Oliver Goetze; Christoph Erdmann 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 418 KB

## Abstract Entacapone (EN) improves the efficacy of levodopa/dopadecarboxylase inhibitor (LD/DDI) formulations by inhibition of the enzyme catechol‐__O__‐methyltransferase (COMT). COMT inhibition also promotes the synthesis of basic LD metabolites, whereas DDI support the composition of acidic LD