Entacapone improves the pharmacokinetic and therapeutic response of controlled release levodopa/carbidopa in Parkinson’s patients
✍ Scribed by F. Stocchi; L. Barbato; G. Nordera; A. Bolner; T. Caraceni
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 181 KB
- Volume
- 111
- Category
- Article
- ISSN
- 1435-1463
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In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari
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