Effect of entacapone on plasma homocysteine levels in Parkinson’s disease patients
✍ Scribed by Martin Nevrly; Petr Kanovsky; Hana Vranova; Katerina Langova; Petr Hlustik
- Publisher
- Springer Milan
- Year
- 2010
- Tongue
- English
- Weight
- 196 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1590-1874
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## Abstract Homocysteine (Hcy) is a risk factor for vascular diseases, cognitive impairment, and dementia. Elevated plasma concentrations of Hcy have been found recently in Parkinson's disease (PD) patients treated with levodopa, suggesting that levodopa is a cause of hyperhomocysteinemia (HHcy). T
## Abstract Levodopa (L‐dopa) administered with a dopadecarboxylase inhibitor (DDI) increases homocysteine plasma levels. This may support the onset of atherosclerosis‐related disorders and neuropsychiatric complications in patients with Parkinson's disease (PD). This homocysteine elevation is cons
## Abstract Entacapone (EN) improves the efficacy of levodopa/dopadecarboxylase inhibitor (LD/DDI) formulations by inhibition of the enzyme catechol‐__O__‐methyltransferase (COMT). COMT inhibition also promotes the synthesis of basic LD metabolites, whereas DDI support the composition of acidic LD