Enhanced Deoxyribonuclease Activity in Human Transformed Cells and in Bloom's Syndrome Cells

✍ Scribed by Mauro Mezzina; Silvano Nocentini; Jeannette Nardelli; Georges Renault; Ethel Moustacchi; Alain Sarasin

• Book ID: 102944228
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 568 KB
• Volume: 2
• Category: Article
• ISSN: 0899-1987
• DOI: 10.1002/mc.2940020402

✦ Synopsis

Human hereditary diseases such as xeroderma pigmentosum, Fanconi's anemia, ataxia telangiectasia, and Bloom's syndrome are characterized by a proneness for developing cancer associated with abnormalities in the processing of DNA damage. The molecular defects responsible for predisposing human tissues t o cancer are still not well understood, despite the fact that a considerable amount o f work has already been done on this problem. In this paper, w e show that in human tumor cell lines, in cells transformed by DNA tumor viruses, and in cells derived from certain cancer-prone disorders, the level of activity o f a 42-kDa deoxyribonuclease is many times higher than in diploid untransformed control cells. This suggests that this activity is linked to, or may play a role in, malignant transformation.