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Altered DNA ligase I activity in Bloom's syndrome cells

✍ Scribed by Chan, John Y. H.; Becker, Frederick F.; German, James; Ray, James H.

Book ID: 109748180
Publisher: Nature Publishing Group
Year: 1987
Tongue: English
Weight: 367 KB
Volume: 325
Category: Article
ISSN: 0028-0836
DOI: 10.1038/325357a0

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Human hereditary diseases such as xeroderma pigmentosum, Fanconi's anemia, ataxia telangiectasia, and Bloom's syndrome are characterized by a proneness for developing cancer associated with abnormalities in the processing of DNA damage. The molecular defects responsible for predisposing human tissue