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DNA ligase I deficiency in Bloom's syndrome

โœ Scribed by Willis, Anne E.; Lindahl, Tomas


Book ID
109748179
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
369 KB
Volume
325
Category
Article
ISSN
0028-0836

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A significant decrease in DNA ligase activity was observed in lymphocytes and fibroblasts of a patient with Fanconi's anemia (FA). This decrease is related to the observed DNA repair deficiency indicated by the delayed closing of repair DNA strands following UV irradiation. Other steps of DNA repair