✦ LIBER ✦

Deficiency of DNA ligase activity in Fanconi's anemia

✍ Scribed by Monica Hirsch-Kauffmann; Manfred Schweiger; Erwin F. Wagner; Karl Sperling

Publisher: Springer
Year: 1978
Tongue: English
Weight: 399 KB
Volume: 45
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00277570

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✦ Synopsis

A significant decrease in DNA ligase activity was observed in lymphocytes and fibroblasts of a patient with Fanconi's anemia (FA). This decrease is related to the observed DNA repair deficiency indicated by the delayed closing of repair DNA strands following UV irradiation. Other steps of DNA repair were analyzed in the FA fibroblasts, including endonucleolytic incision of DNA, repair DNA synthesis, and exonucleolytic removal of the photoproducts. No differences were found against control cells. The action of DNA ligase is delayed during replication in the FA cells, as seen by an accumulation of replicative intermediates.

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