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Mutagenic effects of isonicotinic acid hydracide in Fanconi's anemia

✍ Scribed by Traute M. Schroeder; Christine Stahl-Maugé

Publisher: Springer
Year: 1979
Tongue: English
Weight: 717 KB
Volume: 52
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00278680

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✦ Synopsis

Isonicotinic acid hydracide (INH) increases substantially the chromosomal instability in Fanconi's anemia (FA) cells. The same concentrations of INH do not significantly break chromosomes in heterozygous or normal cells. INH does not induce alkylation or cross-links in the DNA, like other mutagens known to increase breakage in FA cells. Possible mechanisms of the effect of INH are discussed. One consequence of this experiment is the possibility of an exact and doubtless prenatal diagnosis of a homozygous FA fetus.

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