Guided by a long-term retrospective observa-bone lesions (n ϭ 27), which remained asymption, the clinical course and treatment of Langer-tomatic or showed a remission to treatment, hans'-cell histiocytosis (LCH) in adult patients multifocal LCH had a more aggressive course. are represented. The seri
Endocrine manifestations of Langerhans cell histiocytosis diagnosed in adults
✍ Scribed by M. S. García Gallo; M. P. Martínez; M. S. Abalovich; S. Gutiérrez; M. A. Guitelman
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 303 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1386-341X
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A study of 47 well-documented patients with Langerhans cell histiocytosis (LCH) showed a slight female preponderance, with onset as late as the ninth decade. The skin was the commonest site of presentation, but pulmonary and bone involvement was frequent. Patients with single-site disease did best.
Background. Langerhans' cell histiocytosis (LCH) is an uncommon, poorly understood granulomatous disease, characterized by the idiopathic proliferation of Langerhan's cells or their marrow precursors. In 1985, the Philadelphia Workshop adopted the term "Langerhans' cell histiocytosis" (LCH) to diffe