𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Langerhans' cell histiocytosis: Head and neck manifestations in children

✍ Scribed by Mr. Muhammad S. Quraishi; Mr. Alexander W. Blayney; Mr. David Walker; Mr. Fin B. Breatnach; Mr. Patrick J. Bradley

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
596 KB
Volume
17
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Background. Langerhans' cell histiocytosis (LCH) is an uncommon, poorly understood granulomatous disease, characterized by the idiopathic proliferation of Langerhan's cells or their marrow precursors. In 1985, the Philadelphia Workshop adopted the term "Langerhans' cell histiocytosis" (LCH) to differentiate it from reactive and neoplastic causes of histiocytosis.

Methods. This study includes 73 pediatric patients diagnosed with this condition in Dublin, Ireland, and Nottingham, England, during a 34-year period (1959 to 1993). These patients are reviewed with respect to clinical presentation, difficulty with making a histological diagnosis, their management, and outcome.

Resufrs. A total of 49 patients (67%) had head and neck involvement. Bony involvement was the most frequent sign, most frequently located in the skull. There were 11 deaths (15%) in this series, all associated with multisystem disease, and nine of these deaths were in children younger than 2 years of age.

Conclusions. The role of otolaryngologists is important in the early and accurate evaluation, staging, and diagnosis

πŸ“œ SIMILAR VOLUMES

Neuropsychologic deficits in children wi
Neuropsychologic deficits in children with Langerhans cell histiocytosis
✍ Whitsett, Stan F.; Kneppers, Kirstie; Coppes, Max J.; Egeler, R. Maarten πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 164 KB πŸ‘ 2 views

Background. Manifestations of Langerhans cell histiocytosis (LCH) in children range from only a rash, to bony lesions accompanied by pain, to major organ disease. When the central nervous system (CNS) is affected, the LCH patient may exhibit signs and symptoms of hypothalamic and pituitary dysfuncti

Langerhans'-cell histiocytosis in adults
Langerhans'-cell histiocytosis in adults
✍ Baumgartner, Iris; von Hochstetter, Arthur; Baumert, Brigitta; Luetolf, Urs; Fol πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 197 KB πŸ‘ 1 views

Guided by a long-term retrospective observa-bone lesions (n Ο­ 27), which remained asymption, the clinical course and treatment of Langer-tomatic or showed a remission to treatment, hans'-cell histiocytosis (LCH) in adult patients multifocal LCH had a more aggressive course. are represented. The seri

Etoposide in the treatment of six childr
Etoposide in the treatment of six children with langerhans cell histiocytosis (histiocytosis X)
✍ Viana, Marcos Borato ;Oliveira, Benigna Maria ;Silva, Celia Maria ;Leite, Virgin πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 548 KB

Six children received etoposide as the single agent for treatment of Langerhans cell histiocytosis (LCH; histiocytosis X). Five were less than 2 years old at diagnosis. All had multiorgan involvement; one had liver and pulmonary dysfunction. Two infants also had clinical signs of immune deficiency.

Langerhans cell histiocytosis in childre
Langerhans cell histiocytosis in children under 2 years of age
✍ Rivera-Luna, Roberto; Alter-Molchadsky, Nejemie; Cardenas-Cardos, RocΓ­o; MartΓ­ne πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 723 KB

This is a retrospective study of 55 children under the age of 2 years diagnosed with Langerhans cell histiocytosis (LCH). They were classified according to age and organ function and dysfunction following Lahey's criteria. The studied population was divided into four groups by age of diagnosis (0-6,