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Etoposide in the treatment of six children with langerhans cell histiocytosis (histiocytosis X)

✍ Scribed by Viana, Marcos Borato ;Oliveira, Benigna Maria ;Silva, Celia Maria ;Leite, Virginia Hora Rios

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
548 KB
Volume
19
Category
Article
ISSN
0098-1532

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✦ Synopsis

Six children received etoposide as the single agent for treatment of Langerhans cell histiocytosis (LCH; histiocytosis X). Five were less than 2 years old at diagnosis. All had multiorgan involvement; one had liver and pulmonary dysfunction. Two infants also had clinical signs of immune deficiency. Complete response was observed in five. There was no major toxicity. Although three of four evaluable patients relapsed, the drug was considered useful in moving the children from a symptomatic to an asymptomatic clinical status. Etoposide may become a "first-line" drug in the treatment of systemic LCH, especially when the side effects of steroid therapy are considered unacceptable.

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