Viana et al. [I] described their experience with etoposide (VP-16) as initial therapy in the management of patients with Langerhans cell histiocytosis (LCH). However, caution should be used in advocating the use of an epipodophyllotoxin as the "drug of choice" for the treatment of this disorder. Alt
Histiocytosis syndromes in children: II. Approach to the clinical and laboratory evaluation of children with langerhans cell histiocytosis
✍ Scribed by Broadbent, Valerie ;Gadner, Helmut ;Komp, Diane M. ;Ladisch, Stephan
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 348 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
Langerhans cell histiocytosis (LCH) has Society. Adoption of a uniform clinical/labopresented problems in diagnosis and in ratory approach to these children, coupled treatment.Thedefinitivediagnosis isapatho-with agreed-upon steps to the pathologic logic one. To advance thorough and uni-identification of LCH, should result in a betform assessment of these patients, the ele-ter understanding and ultimately better and ments of a complete clinical and laboratory more rational therapies for the disease. evaluation are presented by the Histiocyte histiocytosis, Langerhans cell From the Clinical Working Group who met in Cambridge in March 1988. Members include Drs. V. Broadbent, A. Ceci, A. Chu, G.
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## Abstract Fifty‐two pediatric patients with Langerhans cell histiocytosis (LCH) were diagnosed at the Emma Kinderziekenhuis (EKZ) in Amsterdam over a 20‐year period. Eight patients with multiorgan involvement with organ dysfunction and ten patients with multiorgan involvement without organ dysfun
## Abstract ## Background Current theory on the etiology of Langerhans cell histiocytosis (LCH), formerly Histiocytosis‐X, is that abnormality(ies) of the immune system are responsible for dysregulation of Langerhans cells (LC) in patients' lesions. Among the known abnormalities in LCH patients ar