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Enantioselective Total Synthesis of (−)-α-Kainic Acid

✍ Scribed by Farwick, Andreas; Helmchen, Günter


Book ID
126419287
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
345 KB
Volume
12
Category
Article
ISSN
1523-7060

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New enantioselective approach to the tot
✍ Almudena Rubio; Jesús Ezquerra; Ana Escribano; Modesto Jesús Remuiñán; Juan José 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 269 KB

The total synthesis of (-)-ot-Kainic Acid 1 has been accomplished using ethyl N-Bocpyroglutamate 2 as starting material. The isopropenyl appendage was achieved from the elimination of the dimethylcarbinol introduced at C-4 via an aldol condensation of the lactam enolate of 2 and acetone. The acetate