Enantioselective total synthesis of salicylihalamides A and B
β Scribed by Denis Labrecque; Sylvie Charron; Rabindra Rej; Charles Blais; Serge Lamothe
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 99 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
We have devised a total synthesis of (12R,13S,15R) salicylihalamides A and B, which allowed revision of the absolute stereochemistry of the natural compounds. The same strategy was then applied to the preparation of naturally occurring salicylihalamides.
π SIMILAR VOLUMES
## Abstract The paper illustrates two efficient routes to macrolactone **19** containing a 3β(__para__βmethoxybenzyloxy)propyl side chain at Cβ15. The chiral center at Cβ15 was introduced by a Noyori reduction of keto ester **5**. The intermediate common to both routes, aldehyde **8**, was prepared