Enantioselective total synthesis of (+)-pumiliotoxin A
β Scribed by Overman, Larry E.; Lin, Nan Horng
- Book ID
- 111680019
- Publisher
- American Chemical Society
- Year
- 1985
- Tongue
- English
- Weight
- 278 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The convergent total synthesis of pumiliotoxins by attachment of the side chain to a suitably functionalized core indolizidinone derivative has been achieved. The use of an aldoltype addition condensation strategy, intended to provide for the stereoselective generation of the exocyclic double bond,
Pumiliotoxin C (Q is one of a large group of structurally related toxins which have been isolated from shin extracts of the colorful Central American poison arrow frog Dendrobates pu milio 2, 3, 4, 5c . Synthetic investigations in several laboratories culminated in 1975 in three total syniheses of t