Enantioselective Total Synthesis of Avarol and Avarone
โ Scribed by Taotao Ling; Alan X. Xiang; Emmanuel A. Theodorakis
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 95 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Stereoselective Synthesis of (+)-Avarol, (+)-Avarone, and Some Nonracemic Analogues. -The key step in the synthesis of the title compounds (VIII) and (IX) and the analogue (VII) is Li/NH3-mediated reduction of the enone (III) and subsequent trapping of the intermediate with the bromide (IV). The de
While sesquiterpene illudins M and S (1 and 2, respectively) are highly cytotoxic compounds isolated from Omphalotus illudens, a semisynthetic derivative, (ร)-irofulven (4; hydroxymethyl acylfulvene (HMAF)), has recently demonstrated far superior efficacy as an antitumor agent. [1, 2] (ร)-Irofulven