Enantioselective Total Synthesis of (−)-
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Mohammad Movassaghi; Grazia Piizzi; Dustin S. Siegel; Giovanni Piersanti
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Article
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2006
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John Wiley and Sons
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English
⚖ 145 KB
👁 1 views
While sesquiterpene illudins M and S (1 and 2, respectively) are highly cytotoxic compounds isolated from Omphalotus illudens, a semisynthetic derivative, (À)-irofulven (4; hydroxymethyl acylfulvene (HMAF)), has recently demonstrated far superior efficacy as an antitumor agent. [1, 2] (À)-Irofulven