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Enantioselective synthesis of the ester side chain of homoharringtonine

✍ Scribed by Laurent Keller; Françoise Dumas; Jean d'Angelo

Book ID
104230166
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
89 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The Michael adduct 6 was converted in ten steps with an overall yield of 5.7% into the methyl ester derivative of the side chain of homoharringtonine, (R)-17.

📜 SIMILAR VOLUMES

ChemInform Abstract: Enantioselective Sy
ChemInform Abstract: Enantioselective Synthesis of the Ester Side Chain of Homoharringtonine (IX).
✍ Laurent Keller; Francoise Dumas; Jean d'Angelo 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Construction of Chiral Tertiary Alcohol
Construction of Chiral Tertiary Alcohol Stereocenters via the [2,3]- Meisenheimer Rearrangement: Enantioselective Synthesis of the Side-Chain Acids of Homoharringtonine and Harringtonine
✍ Yang, Hua; Sun, Moran; Zhao, Shuguang; Zhu, Ming; Xie, Yangla; Niu, Changling; L 📂 Article 📅 2012 🏛 American Chemical Society 🌐 English ⚖ 645 KB

For the first time, the [2,3]-Meisenheimer rearrangement has been developed into a general strategy for the construction of chiral tertiary alcohols. The effectiveness and practicality of this methodology are illustrated by the successful synthesis of (R)-20 and (R)-30, the side chain acids of homoh