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Construction of Chiral Tertiary Alcohol Stereocenters via the [2,3]- Meisenheimer Rearrangement: Enantioselective Synthesis of the Side-Chain Acids of Homoharringtonine and Harringtonine

✍ Scribed by Yang, Hua; Sun, Moran; Zhao, Shuguang; Zhu, Ming; Xie, Yangla; Niu, Changling; Li, Chunlin


Book ID
118265045
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
645 KB
Volume
78
Category
Article
ISSN
0022-3263

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Construction of Chiral Tertiary Alcohol
✍ Yang, Hua; Sun, Moran; Zhao, Shuguang; Zhu, Ming; Xie, Yangla; Niu, Changling; L πŸ“‚ Article πŸ“… 2012 πŸ› American Chemical Society 🌐 English βš– 645 KB

For the first time, the [2,3]-Meisenheimer rearrangement has been developed into a general strategy for the construction of chiral tertiary alcohols. The effectiveness and practicality of this methodology are illustrated by the successful synthesis of (R)-20 and (R)-30, the side chain acids of homoh