✦ LIBER ✦

Enantioselective Synthesis of α,α-Difluoro-β-amino Acid and 3,3-Difluoroazetidin-2-one via the Reformatsky-Type Reaction of Ethyl Bromodifluoroacetate with Chiral 1,3-Oxazolidines

✍ Scribed by Marcotte, Stéphane; Pannecoucke, Xavier; Feasson, Christian; Quirion, Jean-Charles

Book ID: 111900918
Publisher: American Chemical Society
Year: 1999
Tongue: English
Weight: 90 KB
Volume: 64
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo990868b

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

ChemInform Abstract: Enantioselective Sy

ChemInform Abstract: Enantioselective Synthesis of α,α-Difluoro-β-amino Acid and 3,3-Difluoroazetidin-2-one via the Reformatsky-Type Reaction of Ethyl Bromodifluoroacetate with Chiral 1,3-Oxazolidines.

✍ Stephane Marcotte; Xavier Pannecoucke; Christian Feasson; Jean-Charles Quirion 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 1 views

Convenient Asymmetric Synthesis of β-Tri

Convenient Asymmetric Synthesis of β-Trifluoromethyl-β-amino Acid, β-Amino Ketones, and γ-Amino Alcohols via Reformatsky and Mannich-Type Reactions from 2-Trifluoromethyl-1,3-oxazolidines.

✍ Florent Huguenot; Thierry Brigaud 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

Lewis acid activation of chiral 2-triflu

Lewis acid activation of chiral 2-trifluoromethyl-1,3-oxazolidines. Application to the stereoselective synthesis of trifluoromethylated amines, α- and β-amino acids

✍ Nicolas Lebouvier; Christophe Laroche; Florent Huguenot; Thierry Brigaud 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 84 KB

The reaction of chiral 2-trifluoromethyl-1,3-oxazolidines with various silylated nucleophiles under Lewis acid activation provides a stereoselective route to functionalized a-trifluoromethylamines. This methodology was successfully applied to the diastereoselective synthesis of trifluoromethylated h

ChemInform Abstract: Synthesis of α-Fluo

ChemInform Abstract: Synthesis of α-Fluoro-β-amino Acids via the Reformatsky Reaction of Chiral N-tert-Butylsulfinylimines with Ethyl Bromofluoroacetate.

✍ Zhi Tao Jing; Yan Gen Huang; Feng Ling Qing 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

Effective Methods for the Synthesis of N

Effective Methods for the Synthesis of N-Methyl β-Amino Acids from All Twenty Common α-Amino Acids Using 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones.

✍ Andrew B. Hughes; Brad E. Sleebs 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 19 KB 👁 1 views

Effective Methods for the Synthesis of N

Effective Methods for the Synthesis of N-Methyl β-Amino Acids from All Twenty Common α-Amino Acids Using 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones

✍ Andrew B. Hughes; Brad E. Sleebs 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 278 KB

N-Methyl b-amino acids are generally required for application in the synthesis of potentially bioactive modified peptides and other oligomers. Previous work highlighted the reductive cleavage of 1,3-oxazolidin-5-ones to synthesise N-methyl a-amino acids. Starting from a-amino acids, two approaches w