The Michael adduct 6 was converted in ten steps with an overall yield of 5.7% into the methyl ester derivative of the side chain of homoharringtonine, (R)-17.
Enantioselective Synthesis of the Ester Side Chain of Homoharringtonine
✍ Scribed by Laurent Keller; Françoise Dumas; Jean d’Angelo
- Book ID
- 102176740
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 202 KB
- Volume
- 2003
- Category
- Article
- ISSN
- 1434-193X
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
For the first time, the [2,3]-Meisenheimer rearrangement has been developed into a general strategy for the construction of chiral tertiary alcohols. The effectiveness and practicality of this methodology are illustrated by the successful synthesis of (R)-20 and (R)-30, the side chain acids of homoh