Highly Enantioselective Synthesis of α-T
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Peng Li; Gang Zhao; Shizheng Zhu
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Article
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2011
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John Wiley and Sons
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English
⚖ 151 KB
👁 1 views
## Abstract An enantioselective Michael addition of ethyl 4,4,4‐trifluoro‐3‐oxobutanoate to __α__,__β__‐unsaturated ketone esters using a chiral alkyl‐substituted thiourea catalyst is reported. Excellent levels of stereo‐induction (up to 98% __ee__) under mild reaction conditions were obtained to a