A Convenient Synthesis of the Echinacea-
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Anne-Marie Lamidey; Lionel Fernon; Laurent PouysΓ©gu; Charlotte Delattre; StΓ©phan
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Article
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2002
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John Wiley and Sons
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German
β 87 KB
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The Echinacea-derived immunostimulator and HIV-1 integrase inhibitor (Γ)-chicoric acid ( 2,3-bis{[3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enyl]oxy}butanedioic acid; 1a) was conveniently prepared via a silanepromoted Pd-mediated chemoselective hydrogenolysis of its perbenzylated derivative 12a, which was