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Enantioselective synthesis of (-)-kainic acid

✍ Scribed by Takano, Seiichi.; Sugihara, Takumichi.; Satoh, Shigeki.; Ogasawara, Kunio.


Book ID
125942073
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
653 KB
Volume
110
Category
Article
ISSN
0002-7863

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The total synthesis of (-)-ot-Kainic Acid 1 has been accomplished using ethyl N-Bocpyroglutamate 2 as starting material. The isopropenyl appendage was achieved from the elimination of the dimethylcarbinol introduced at C-4 via an aldol condensation of the lactam enolate of 2 and acetone. The acetate