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Enantioselective Synthesis of Chiral β-Aryloxy Alcohols by Asymmetric Hydrogenation of α-Aryloxy Aldehydes via Dynamic Kinetic Resolution

✍ Scribed by Zhang-Tao Zhou; Jian-Hua Xie; Qi-Lin Zhou

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
174 KB
Volume
351
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

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A catalytic enantioselective hydrogenation of racemic α‐aryloxy aldehydes via dynamic kinetic resolution has been developed by using (diamine)(spirodiphosphine)ruthenium(II) chloride [RuCl~2~(SDPs)(diamine)] catalysts. Employing this new reaction system a variety of optically active β‐aryloxy primary alcohols were synthesized in high yields and moderate to good enantioselectivities.

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