✍ Scribed by J. A. O'MEARA; N. GARDEE; M. JUNG; R. N. BEN; T. DURST
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Enantioselective Synthesis of β-Dibenzylamino Alcohols via a Dynamic Kinetic Resolution of α-Halo Acids.
-The title compounds (IV), precursors of synthetically important Reetz aldehydes, are prepared by highly diastereoselective amination of α-bromo esters (I). The high yields obtained in this amination are explained by a dynamic kinetic resolution process in which the (R,R) isomer of (I) reacts more quickly with the amine than the (S,R) isomer, and the released bromide or the added iodide serve to epimerize the slow reacting isomer. -(O'MEARA,
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## Abstract magnified image A catalytic enantioselective hydrogenation of racemic α‐aryloxy aldehydes __via__ dynamic kinetic resolution has been developed by using (diamine)(spirodiphosphine)ruthenium(II) chloride [RuCl~2~(SDPs)(diamine)] catalysts. Employing this new reaction system a variety of
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