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Enantioselective Synthesis of (2 S ,3 R )-3-Hydroxy-3-methylproline, A Novel Amino Acid Found in Polyoxypeptins

✍ Scribed by Qin, Dong-Guang; Zha, Hui-Yan; Yao, Zhu-Jun


Book ID
126429095
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
49 KB
Volume
67
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES


Synthetic study of polyoxypeptin: stereo
✍ Yasuo Noguchi; Hiromi Uchiro; Tatsuhiro Yamada; Susumu Kobayashi πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 72 KB

The first synthesis of (2S,3R)-3-hydroxy-3-methylproline, which is a novel amino acid of polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma AsPC-1, was accomplished. The key feature of the synthesis is the palladium-catalyzed intramolecular N-allylation of alkenyloxirane to t

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✍ Kazuishi Makino; Ai Kondoh; Yasumasa Hamada πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 75 KB

Stereoselective synthesis of (2S,3R)-3-hydroxy-3-methylproline (3), a component of polyoxypeptins, has been achieved by use of SmI 2 -mediated diastereoselective cyclization reaction as a key step.