The first synthesis of (2S,3R)-3-hydroxy-3-methylproline, which is a novel amino acid of polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma AsPC-1, was accomplished. The key feature of the synthesis is the palladium-catalyzed intramolecular N-allylation of alkenyloxirane to t
β¦ LIBER β¦
Enantioselective Synthesis of (2 S ,3 R )-3-Hydroxy-3-methylproline, A Novel Amino Acid Found in Polyoxypeptins
β Scribed by Qin, Dong-Guang; Zha, Hui-Yan; Yao, Zhu-Jun
- Book ID
- 126429095
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 49 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Synthetic study of polyoxypeptin: stereo
β
Yasuo Noguchi; Hiromi Uchiro; Tatsuhiro Yamada; Susumu Kobayashi
π
Article
π
2001
π
Elsevier Science
π
French
β 72 KB
Polyoxypeptin isolated from Streptomyces
β
Kazuo Umezawa; Kumi Nakazawa; Toshio Uemura; Yoko Ikeda; Shinichi Kondo; Hiroshi
π
Article
π
1998
π
Elsevier Science
π
French
β 268 KB
Synthetic studies on polyoxypeptins: ste
β
Kazuishi Makino; Ai Kondoh; Yasumasa Hamada
π
Article
π
2002
π
Elsevier Science
π
French
β 75 KB
Stereoselective synthesis of (2S,3R)-3-hydroxy-3-methylproline (3), a component of polyoxypeptins, has been achieved by use of SmI 2 -mediated diastereoselective cyclization reaction as a key step.
ChemInform Abstract: Polyoxypeptins A an
β
Kazuo Umezawa; Kumi Nakazawa; Yoko Ikeda; Hiroshi Naganawa; Shinichi Kondo
π
Article
π
2010
π
John Wiley and Sons
β 30 KB
A Short-Step Synthesis of (2S,3R)-3-Hydr
β
Kazuishi Makino; Tatsuya Suzuki; Yasumasa Hamada
π
Article
π
2005
π
John Wiley and Sons
β 16 KB
π 1 views
## Abstract For Abstract see ChemInform Abstract in Full Text.
(2S,3S,4R)-4-Amino-3-hydroxy-2-methylpen
β
Robert M. DiPardo; Mark G. Bock
π
Article
π
1983
π
Elsevier Science
π
French
β 189 KB
2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid has been synthesized through acylation of a chiral enolate and subsequent stereoselective reduction.